Polynucleotides: The innovative revolution in skin rejuvenation and regeneration

Biostimulation for radiant skin – with a safe, clinically proven technology.

Natural regeneration for the face, neck, hands and more

Polynucleotides activate the natural regeneration processes of your skin. They promote the production of collagen and elastin, increase skin hydration and improve skin elasticity. This innovative treatment method is effective for premature skin ageing, wrinkles, scars and light-damaged skin.

The treatment is particularly suitable for:

Fine lines and wrinkles
Tired, sagging skin
Scars and acne scars
Light-damaged skin
Dehydrated skin

Polynucleotides are natural, well tolerated and ensure a visibly more even, hydrated complexion. The result is long-lasting hydrated, smooth and firm skin – without any synthetic materials.

What makes polynucleotides so special?

Polynucleotides are naturally occurring DNA and RNA components derived from freshwater fish. This unique form of biostimulation activates the body’s natural regeneration processes by encouraging fibroblasts to produce new collagen and elastin. Unlike fillers, polynucleotides work as bioactivators, giving your skin the boost it needs to renew itself—delivering results that are not only visible but also long-lasting.

How does the treatment work?

During the short, comfortable session (20-30 minutes), polynucleotides are injected into the skin using fine needles. It binds water, soothes the skin and activates the body’s own regeneration process. An anesthetic cream can be applied if desired.

The compelling benefits of polynucleotides

Natural regeneration

Activate your skin’s self-healing powers and stimulate collagen and elastin production.

Hydration and freshness

Polynucleotides bind water in the skin, providing long-lasting hydration and elasticity.

Versatile applications

Popular treatment areas include the face, neck, décolleté, scalp, and hands—plus targeted care for scars and acne scars.

Safe and gentle

Derived from freshwater fish, the natural ingredients are clinically tested and suitable for all skin types, even sensitive skin.

Anti-inflammatory properties

Polynucleotides soothe the skin, reduce redness, and promote an even complexion.

FAQs about polynucleotide treatments

How many treatments are necessary, and are there side effects?

Three sessions are recommended, spaced 3 to 6 weeks apart. Mild redness or bruising at the injection sites typically fades quickly and can be easily covered with makeup.

How long do the results last?

Results vary depending on skin type, age, and metabolism. Many patients opt for a touch-up after 1–3 months and choose to repeat the treatment annually.

Which areas can be treated?

Polynucleotides are effective for the face, neck, décolleté, hands, and even the scalp to stimulate hair growth. They can also be used to treat scars and acne scars.

Who is the treatment suitable for?

This treatment is suitable for all skin types and age groups, particularly for those with premature aging, sun-damaged, or dehydrated skin. However, it is not suitable for individuals with fish allergies, autoimmune diseases, or allergies to the active ingredients. Feel free to contact us with any questions.

What should be considered before and after the treatment?

Avoid blood-thinning medications one week before and after the treatment. Refrain from sports, saunas, and sun exposure for 1–2 days following the procedure.

Backed by Science

These publications provide a comprehensive overview of the current applications and effectiveness of polynucleotides in aesthetic medicine:

Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness, International Journal of Molecular Sciences, 2024; 25(15): 8224.

This review article examines the current status of the use of polynucleotides in aesthetic medicine and evaluates their perceived effectiveness.

The Effectiveness of Polynucleotides in Esthetic Medicine, Journal of Cosmetic Dermatology, 2023.

This study evaluates the effectiveness of polynucleotide injections in reducing wrinkles, improving skin texture and increasing elasticity.

Polynucleotides and their application in aesthetic medicine, Aesthetic Dermatology & Cosmetology, 2023; 15: 24-26.

This article highlights the diverse mechanisms of action of polynucleotides and their potential applications in aesthetic medicine, particularly for skin rejuvenation and scar treatment.